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Inadequate/Comprehensive Metabolizers, CYP2D6 The formation of your Energetic metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. About 7% from the populace has diminished exercise from the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme procedure. These folks are “inadequate metabolizers” of debrisoquine, dextromethorphan and
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